The Demon came across an interesting post by Daniel Adler entitled, Lamentation for the Comma, in which he states, "Oh, comma! Dear friend, connector of clauses, I am ridding my writing of you!" He correctly observes that commas are "sometimes burdensome."
Thus, it easy to imagine Lady Macbeth declaring, "Out, damn'd comma! out, I say!" Or maybe it should be “Out damn’d comma! out I say!” Okay, it's easy to imagine if you're me!
But as a counterpoint, let's invoke Oscar Wilde who said, “I was working on the proof of one of my poems all the morning, and took out a comma. In the afternoon I put it back again."
Commas! You can't live with 'em and you can't live without 'em!